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These products have significant market potential and address unmet medical needs in the growing population of patients with serious lung diseases like pneumonia, cystic fibrosis, bronchiectasis and COPD. With a management http://www.dhs.pa.gov/citizens/healthcaremedicalassistance/ team responsible for several of the top drugs at Genentech and MedImmune, Aridis has advanced its pipeline through significant preclinical milestones using non-dilutive funding totaling over $20 million.
Animal research is not only regulated by legislation but also by self-regulatory mechanisms within the scientific community, which include biomedical journals’ policies on animal use. For editorial policies to meaningfully impact attitudes and practice, they must not only be put into effect by editors and reviewers, but also be set to high standards. The authors present a tool that classifies journals’ policies on animal use-the EXEMPLAR scale-as well as an analysis by this scale of 170 journals publishing studies on animal models of three human diseases: Amyotrophic Lateral Sclerosis, Type-1 Diabetes and Tuberculosis. Results show a much greater focus of editorial policies on regulatory compliance than on other domains, suggesting a transfer of journals’ responsibilities to scientists, institutions and regulators.
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The authors suggest an update to institutional policies that will better inform the public about the use of nonhuman animals in biomedical research, and to improve the dialogue between the research community and animal welfare and rights communities.
Acetone (6000 ml) was added to 4-methoxy-2,3,6 trimethyl benzaldehyde (500.3 g) and the mixture was stirred at 20-30°C. Aqueous solution of sodium hydroxide (134.8 g in 500 ml water) was gradually added to it and the resulting mixture was heated to 45-50°C with continued stirring. After completion of the reaction, as monitored by HPLC, the reaction mass was cooled and acetic acid was added till pH 4.5 to 5.5. Distillation of acetone, followed by addition of cyclohexane to the residue, followed by washing with water, separation and concentration of the organic layer gave 4-(4-methoxy-2,3,6 trimethylphenyl)-but-3-en-2-one of formula (II).